The main objective of the present investigation was to formulate and evaluate the pulsincap for anti diabetic drug miglitol to control the increased blood glucose level after food consumption in diabetic patient by allowing the drug to release immediately after meals. Initially miglitol immediate release tablets were prepared using different concentrations of sodium starch glycollate as superdisintegrant and selected the best formulation for the development of pulsincap of miglitol. Miglitol pulsincaps were prepared by using different concentrations of hydrophilic polymer HPMC K4M as hydrogel plug. The ideal concentration of hydrogel plug was selected based on the invitro drug release profile and desired lag time of 4 hrs. The Invitro release studies were carried out for the formulated miglitol pulsincaps using different buffer solutions such as pH 1.2,7.4 and 6.8.The invitro drug release profile of miglitol pulsincaps containining 60mg of HPMC K4M as hydrogel plug exhibited a time period of 4 hrs without drug release (lag time) followed by a rapid release of drug. Hence the developed formulation was found to be suitable for the diabetic patient to manage the blood glucose levels which are high after food consumption.
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